I. Introduction Definition of ACTH Adrenocorticotropic hormone (ACTH) is a hormone that the pituitary gland produces and releases in reaction to stress. The body’s use of ACTH The body’s immune system and stress response are both significantly regulated by ACTH. It causes the adrenal glands to release cortisol, which aids in controlling immunological responses to stress, blood sugar levels, and other physiological processes. Aldosterone and androgens are two additional hormones the adrenal gland generates that are regulated by ACTH. The body’s sources of ACTH Pituitary gland The body’s main source of ACTH is the pituitary gland, which is found near the base of the brain. In response to stress signals from the hypothalamus, it releases ACTH, which causes the adrenal gland to start making cortisol. Adrenal medulla Another source of ACTH is the adrenal gland, which is situated above the kidneys. However, because it is far less powerful than the pituitary gland, this source is often ...